TY  - JOUR
T1  - Approach to correction of apoptotic disorders in children with early diabetic nephropathy
A1  - Ievgeniia Burlaka
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2022
VL  - 12
IS  - 2
DO  - 10.51847/G6i3231Jnm
SP  - 104
EP  - 109
N2  - hypertension, and a decline in renal function. Prominent changes detected in apoptosis controlling factors, i.e. BcL-xL and caspase-3 and require a search for additional non-toxic therapeutic interventions, i.e. antioxidants, anti-apoptotic effectors in addition to glycemic control, hypertension management, as well as albuminuria. The present study included forty-four children (24 boys, 20 girls) diagnosed with T1D and DN around the ages of five-seventeen. Clinical data (age, gender, disease duration, blood pressure), conventional laboratory markers (complete blood count, serum cholesterol, Hb1Ac, GFR, MAU), and apoptosis markers (BcL-xL, caspase-3) were analyzed. We show that apoptosis-induced disorders in children with DN evaluated by dysbalance occurring in the cell death controlling system may be attenuated by the advanced scheme which includes conventional treatment and Vitamin D; the applied scheme has a long-term therapeutic effect on macroalbuminuria development‎.
UR  - https://japer.in/article/approach-to-correction-of-apoptotic-disorders-in-children-with-early-diabetic-nephropathy-qt6keaxynt2k9bl
ER  -