TY  - JOUR
T1  - Acacia tortilis leaf extract alters brain serotonin turnover and stress-induced heart rate variability in laboratory mice
A1  - Shalan Alaamri
A1  - Abdulhalim Serafi
A1  - Aisha Azmat
A1  - Muhammad Ahmed
A1  - Mohammed Bafail
A1  - Umama Noor Siddiqui
JF  - Journal of Advanced Pharmacy Education and Research
JO  - J Adv Pharm Educ Res
SN  - 2249-3379
Y1  - 2026
VL  - 16
IS  - 3
DO  - 10.51847/GYIHGGTdK7
SP  - 10
EP  - 16
N2  - This study aimed to evaluate brain serotonin turnover and its impact on heart rate variability during stress. Six groups of Sprague-Dawley mice received oral treatment for fifteen days. On the 7th day, after the respective treatments, mice were first subjected to restraint stress for 30 min in Decapicone to induce acute stress, and then antidepressant action was assessed by the forced swim test (FST). On the 14th day, ECG was also recorded in anesthetized mice using micro-hook electrodes (AD instrument, PowerLab), and heart rate (HR: beats per minute) and heart rate variability (HRV) were calculated. At the end of the study, brain serotonin (5HT), 5-hydroxyindole acetic acid (5HIAA), and serotonin turnover rate were measured by using a high-performance liquid chromatographic (HPLC) method.

Stress Control (SC) mice showed an increased serotonin (5HT; P
UR  - https://japer.in/article/acacia-tortilis-leaf-extract-alters-brain-serotonin-turnover-and-stress-induced-heart-rate-variabili-jabrfhcex7dg7fm
ER  -