%0 Journal Article
%T Acacia tortilis leaf extract alters brain serotonin turnover and stress-induced heart rate variability in laboratory mice
%A Shalan Alaamri
%A Abdulhalim Serafi
%A Aisha Azmat
%A Muhammad Ahmed
%A Mohammed Bafail
%A Umama Noor Siddiqui
%J Journal of Advanced Pharmacy Education and Research
%@ 2249-3379
%D 2026
%V 16
%N 3
%R 10.51847/GYIHGGTdK7
%P 10-16
%X This study aimed to evaluate brain serotonin turnover and its impact on heart rate variability during stress. Six groups of Sprague-Dawley mice received oral treatment for fifteen days. On the 7th day, after the respective treatments, mice were first subjected to restraint stress for 30 min in Decapicone to induce acute stress, and then antidepressant action was assessed by the forced swim test (FST). On the 14th day, ECG was also recorded in anesthetized mice using micro-hook electrodes (AD instrument, PowerLab), and heart rate (HR: beats per minute) and heart rate variability (HRV) were calculated. At the end of the study, brain serotonin (5HT), 5-hydroxyindole acetic acid (5HIAA), and serotonin turnover rate were measured by using a high-performance liquid chromatographic (HPLC) method.

Stress Control (SC) mice showed an increased serotonin (5HT; P
%U https://japer.in/article/acacia-tortilis-leaf-extract-alters-brain-serotonin-turnover-and-stress-induced-heart-rate-variabili-jabrfhcex7dg7fm